The story takes place over two timelines. The first of which involves 14 year old sisters Jade and Billie Wesker moving to New Raccoon City.
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They come to realise that their father may be concealing dark secrets that could destroy the world. The second timeline takes place over a decade in the future, where only 15 million humans remain, with over 6 billion animals and people being infected with the T-virus. It follows Jade, now thirty, in her efforts to survive in this world.